The next wave of hepatitis C virus: The epidemic of intravenous drug use

@article{Shiffman2018TheNW,
  title={The next wave of hepatitis C virus: The epidemic of intravenous drug use},
  author={Mitchell L Shiffman},
  journal={Liver International},
  year={2018},
  volume={38},
  pages={34 - 39}
}
  • M. Shiffman
  • Published 1 February 2018
  • Medicine
  • Liver International
The epidemic of hepatitis C virus (HCV) began in the 1960s when transmission was primarily the result of blood transfusions. By 1990, when HCV was identified and a serologic test for screening donated blood was implemented, 123 million persons had already become infected worldwide and HCV was the most common cause of cirrhosis, hepatocellular carcinoma and the most common indication for liver transplantation. Approximately 75% of persons with HCV are “baby boomers” born between the years 1945… 
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Update on Hepatitis C Epidemiology: Unaware and Untreated Infected Population Could Be the Key to Elimination
TLDR
To achieve HCV elimination, health programmes should include improvement to access to health care services, increased screening and new projects to identify a submerged portion of patients with HCV infection.
Hepatitis C Virus Envelope Glycoproteins: A Balancing Act of Order and Disorder
TLDR
The structural complexities of HCV E1 and E2 are discussed, and it is suggested that structural flexibility may play a role in shielding antigenic epitopes during infection.
Treatment of early stage chronic hepatitis C virus infection
TLDR
This review evaluates the aspects underlying the benefit of treating chronic HCV infection at the early stage of disease and outlines the considerations that have to be taken into account when planning treatment in patients with HCV and minimal liver disease.
Hepatitis B and C.
TLDR
The epidemiology, virology, immunobiology, prevention, clinical manifestations, evaluation, and the advances in treatment of hepatitis B and C in children are discussed.
Trends of recent hepatitis C virus infection among HIV-positive men who have sex with men in Taiwan, 2011–2018
TLDR
An expanding HCV epidemic among HIV-positive men who have sex with men (MSM) is occurring in Taiwan and improving access to HCV testing and early linkage to treatment are needed to curb the expandingHCV epidemic.
Hepatitis C Virus Structure: Defined by What It Is Not.
TLDR
This review will focus on structural progress on HCV virion, core protein, envelope glycoproteins, and specific host receptors.
Epidemiology and treatment status of hepatitis C virus infection among people who have ever injected drugs in Korea: a prospective multicenter cohort study from 2007 to 2019 in comparison with non-PWID
TLDR
The epidemiological characteristics, but not treatment uptake and outcomes, were different between the PWID and non-PWID groups, and active HCV screening and treatment should be offered to PWID in Korea.
Chronic Hepatitis B Virus in Patients with Chronic Hepatitis C Virus.
TLDR
Patients with hepatitis B surface antigen are at the highest risk for reactivation, and these patients should receive prophylactic treatment of HBV during and for 6 months after HCV treatment.
Hepatitis C virus infection mortality trends according to three definitions with special concern for the baby boomer birth cohort
We examined mortality trends of hepatitis C virus (HCV) infection in the United States in 1999‐2018 according to the following definitions: HCV as the underlying cause of death (UCOD), HCV mentioned…
Expanding Capacity to Treat Hepatitis C: Overcoming Barriers and New Innovations
TLDR
The critical role of expanding treatment capacity to enhance these efforts through a multifaceted strategy which incorporates education, training, and multidisciplinary support across clinical settings such as specialty centers, primary care, community health centers, methadone and substance use programs, prisons, and pharmacy-based clinics is discussed.
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