The next generation of antibody drug conjugates.

  title={The next generation of antibody drug conjugates.},
  author={Fiona Mack and Michael K. Ritchie and Puja Sapra},
  journal={Seminars in oncology},
  volume={41 5},
Antibody-drug conjugates (ADCs) represent a promising therapeutic modality for the clinical management of cancer. The recent approvals of brentuximab vedotin and ado-trastuzumab emtansine plus emerging data for many molecules in clinical trials highlight the potential for ADCs to offer new therapeutic options for patients. Currently, more than 30 ADCs are being evaluated in early- or late-stage clinical trials. Accordingly, much has been done to refine and transform the early-generation ADCs to… CONTINUE READING
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