The newt reprograms mature RPE cells into a unique multipotent state for retinal regeneration

  title={The newt reprograms mature RPE cells into a unique multipotent state for retinal regeneration},
  author={Md. Rafiqul Islam and Kenta Nakamura and Martin Miguel Casco-Robles and Ailidana Kunahong and Wataru Inami and Fubito Toyama and Fumiaki Maruo and Chikafumi Chiba},
  booktitle={Scientific reports},
The reprogramming of retinal pigment epithelium (RPE) cells in the adult newt immediately after retinal injury is an area of active research for the study of retinal disorders and regeneration. We demonstrate here that unlike embryonic/larval retinal regeneration, adult newt RPE cells are not directly reprogrammed into retinal stem/progenitor cells; instead, they are programmed into a unique state of multipotency that is similar to the early optic vesicle (embryo) but preserves certain adult… CONTINUE READING
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