The newborn rat's stress system readily habituates to repeated and prolonged maternal separation, while continuing to respond to stressors in context dependent fashion.

@article{Daskalakis2011TheNR,
  title={The newborn rat's stress system readily habituates to repeated and prolonged maternal separation, while continuing to respond to stressors in context dependent fashion.},
  author={Nikolaos P Daskalakis and Sanne E. F. Claessens and Jasper J L Laboyrie and Leo Enthoven and Melly S. Oitzl and Danielle L. Champagne and Edo Ronald de Kloet},
  journal={Hormones and behavior},
  year={2011},
  volume={60 2},
  pages={165-76}
}
Adrenal corticosterone secretion of newborn mice rapidly desensitizes to repeated maternal absence. The present study investigated the effects of novelty exposure, maternal care and genotype on this phenomenon. Maternal separation (MS) took place on postnatal days (pnd) 3-5. In Wistar rats, the degree of novelty in the MS-environment was varied by exposing pups to: (i) "home separation": pups remained in the home cage; (ii) "novel separation": pups were placed individually in a novel cage… CONTINUE READING