The new tubulin-inhibitor combretastatin A-4 enhances thermal damage in the BT4An rat glioma.

PURPOSE To investigate the toxicity of combretastatin A-4 disodium phosphate (CA-4) and its vascular effects in the subcutaneous (s.c.) BT4An rat glioma, and additionally, to determine the tumor response of CA-4 combined with hyperthermia. METHODS AND MATERIALS For assessment of drug toxicity, rats were given 50, 75, or 100 mg/kg CA-4 and followed by… CONTINUE READING