The new stimulant designer compound pentedrone exhibits rewarding properties and affects dopaminergic activity

@article{Hwang2017TheNS,
  title={The new stimulant designer compound pentedrone exhibits rewarding properties and affects dopaminergic activity},
  author={Ji-Young Hwang and Jun-Sub Kim and Ji-Hwan Oh and Sa-Ik Hong and Shi‐Xun Ma and Yang-Hee Jung and Yong‐Hyun Ko and Seok-Yong Lee and Hyoung‐Chun Kim and Choon-Gon Jang},
  journal={Addiction Biology},
  year={2017},
  volume={22},
  pages={117 - 128}
}
Cathinone derivatives are new recreational drugs known to produce psychostimulant effects. However, unlike other psychostimulants, the addictive potential of cathinone derivatives has not been widely studied. Here, we investigated the effects of pentedrone, a type of cathinone derivative, on the dopaminergic system using reverse transcription polymerase chain reaction and Western blot. We also evaluated the addictive potential of pentedrone using conditioned place preference and self… 

DARK Classics in Chemical Neuroscience: Cathinone-Derived Psychostimulants.

TLDR
Animal studies confirm the rewarding and reinforcing properties of synthetic cathinones by utilizing self-administration, place conditioning, and intracranial self-stimulation assays and additionally show persistent neuropathological features which demonstrate a clear need to better understand this class of drugs.

Role of the nitrogen terminus of pentiophenone derivatives (synthetic cathinones) inducing psychostimulant and rewarding effects

TLDR
The amino-terminus appears to affect the potency of synthetic cathinones regarding their rewarding, psychostimulant and DA and NA uptake inhibiting effects.

Locomotor and reinforcing effects of pentedrone, pentylone and methylone in rats

TLDR
The inference that second generation cathinones pentylone and pentedrone have abuse liability greater than that of methylone is supported.

FINAL DEGREE PROJECT ROLE OF THE DOPAMINE AND SEROTONIN TRANSPORTERS IN ADDICTION: PREDICTION OF THE ABUSE POTENTIAL OF NEW PSYCHOACTIVE SUBSTANCES

  • Biology, Psychology
TLDR
The role of the dopamine transporter and serotonin transporter in addiction is reviewed, and the pharmacological profile of 7 novel synthetic cathinones is described, as well as to compare them with standard psychoactive or prescribed compounds such as cocaine, MDMA, or paroxetine.

Neurochemical and psychopharmacological study of MDPV, a cocaine-like psychostimulant. Characterization of structurally-related second-generation synthetic cathinones

TLDR
This doctoral dissertation aims to contribute to scientific knowledge by providing new insights about MDPV about the neuroadaptive changes underlying its abuse, its addictive properties, its behavioural effects, as well as about its relationship with cocaine, the most consumed psychostimulant worldwide.

An updated review on synthetic cathinones.

TLDR
The present work provides a comprehensive review on history and legal status, chemistry, pharmacokinetics, pharmacodynamics, adverse effects and lethality in humans, as well as on the current knowledge of the neurotoxic mechanisms of synthetic cathinones.

Structure–Activity Relationship of Novel Second-Generation Synthetic Cathinones: Mechanism of Action, Locomotion, Reward, and Immediate-Early Genes

TLDR
The present study demonstrated for the first time that NEP, 4-MPD, and 4-MeAP induce reward in mice, and demonstrated that all tested synthetic cathinones are potent dopamine uptake inhibitors, especially the N-ethyl analogs, while the ring-substituted cathinone tested showed higher potency as SERT inhibitors than their no ring- Substituting analogs.

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