The new species Brucella microti replicates in macrophages and causes death in murine models of infection.

@article{JimnezdeBags2010TheNS,
  title={The new species Brucella microti replicates in macrophages and causes death in murine models of infection.},
  author={Mar{\'i}a Pilar Jim{\'e}nez de Bag{\"u}{\'e}s and Safia Ouahrani-Bettache and Juan F. Quintana and Olga Mitjana and Nabil Hanna and St{\'e}phanie Bessoles and Françoise Sanchez and Holger Christian Scholz and Virginie Lafont and Stephan K{\"o}hler and Alessandra Occhialini},
  journal={The Journal of infectious diseases},
  year={2010},
  volume={202 1},
  pages={
          3-10
        }
}
BACKGROUND The recent isolation of Brucella microti from the common vole, the red fox, and the soil raises the possibility of an eventual reemergence of brucellosis in Europe. In this work, the pathogenic potential of this new Brucella species in both in vitro and in vivo models of infection was analyzed. METHODS The ability of B. microti (as compared to that of the closely related species Brucella suis) to replicate in human macrophages and in human and murine macrophage-like cells was… 
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Course of Infection with the Emergent Pathogen Brucella microti in Immunocompromised Mice
TLDR
The results indicate that T and/or B cells are required for the control of infection with the mouse pathogen Brucella microti in liver and spleen but that NK cells are crucial for survival in the absence of B and T cells, and suggest that controlled granuloma formation is critical to clear this type of infection in wt mice.
The virB operon is essential for lethality of Brucella microti in the Balb/c murine model of infection.
TLDR
In this study, the possible involvement of the virB type IV secretion system, a key virulence factor of Brucella sp.
Lethality of Brucella microti in a murine model of infection depends on the wbkE gene involved in O-polysaccharide synthesis
TLDR
Complementation of the R-strains with the wbkE gene restored the smooth phenotype and the ability of B. microti to kill infected mice, demonstrating its importance in pathogenesis.
Brucella neotomae Recapitulates Attributes of Zoonotic Human Disease in a Murine Infection Model
TLDR
The infectious course and pathologies in the murine model showed similarity to prior observations of primate and native host infection with zoonotic Brucella species, and offers a promising system to accelerate and complement experimental work in the genus BrucellA.
Experimental infection of chicken embryos with recently described Brucella microti: Pathogenicity and pathological findings.
Brucella spp. of amphibians comprise genomically diverse motile strains competent for replication in macrophages and survival in mammalian hosts
TLDR
The heterogeneity of these novel strains hampers a single species description but their phenotypic and genetic features suggest that they represent an evolutionary link between a soil-associated ancestor and the mammalian host-adapted pathogenic Brucella species.
The new strains Brucella inopinata BO1 and Brucella species 83-210 behave biologically like classic infectious Brucella species and cause death in murine models of infection.
TLDR
The novel atypical Brucella strains of this study behave like classic intracellular Bru cell pathogens and cause death in murine models of infection, as previously published for B. microti, another recently described environmental and wildlife species.
Survival of Brucella abortus S19 and other Brucella spp. in the presence of oxidative stress and within macrophages
TLDR
From the various Brucellae tested, B. abortus S19 showed the highest susceptibility to oxidative stress and the lowest ability to survive inside of murine macrophages, while B. neotomae, which also belongs to the classical core clade of Brucella and lacks the regulators of the mgl-operon, presented the highest degree of tolerance to H2O2 but not in the survival in macrophage.
Brucella: Reservoirs and Niches in Animals and Humans
TLDR
It is proposed that Brucella takes advantage of the environment provided by the cellular niches in which it resides to generate reservoirs and disseminate to other organs, as well as wildlife reservoirs.
Brucellosis at the animal/ecosystem/human interface at the beginning of the 21st century.
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