The new sequencer on the block: comparison of Life Technology’s Proton sequencer to an Illumina HiSeq for whole-exome sequencing

@article{Boland2013TheNS,
  title={The new sequencer on the block: comparison of Life Technology’s Proton sequencer to an Illumina HiSeq for whole-exome sequencing},
  author={Joseph F. Boland and Charles Y. C. Chung and David E. Roberson and Jason Mitchell and Xijun Zhang and Kate McGee Im and Ji Wei He and Stephen J. Chanock and Meredith Yeager and M. Dean},
  journal={Human Genetics},
  year={2013},
  volume={132},
  pages={1153-1163}
}
We assessed the performance of the new Life Technologies Proton sequencer by comparing whole-exome sequence data in a Centre d’Etude du Polymorphisme Humain trio (family 1463) to the Illumina HiSeq instrument. To simulate a typical user’s results, we utilized the standard capture, alignment and variant calling methods specific to each platform. We restricted data analysis to include the capture region common to both methods. The Proton produced high quality data at a comparable average depth… CONTINUE READING
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