The new low-toxic histone deacetylase inhibitor S-(2) induces apoptosis in various acute myeloid leukaemia cells

@inproceedings{Cellai2012TheNL,
  title={The new low-toxic histone deacetylase inhibitor S-(2) induces apoptosis in various acute myeloid leukaemia cells},
  author={Cristina Cellai and Manjola Balliu and Anna Laurenzana and Luca Guandalini and Rosanna Matucci and Debora Miniati and Eugenio Torre and Angela Nebbioso and Vincenzo Carafa and Lucia Altucci and Maria Novella Romanelli and Francesco Paoletti},
  booktitle={Journal of cellular and molecular medicine},
  year={2012}
}
Histone deacetylase inhibitors (HDACi) induce tumour cell cycle arrest and/or apoptosis, and some of them are currently used in cancer therapy. Recently, we described a series of powerful HDACi characterized by a 1,4-benzodiazepine (BDZ) ring hybridized with a linear alkyl chain bearing a hydroxamate function as Zn(++)--chelating group. Here, we explored the anti-leukaemic properties of three novel hybrids, namely the chiral compounds (S)-2 and (R)-2, and their non-chiral analogue 4, which were… CONTINUE READING
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