The new life of a centenarian: signalling functions of NAD(P).

@article{Berger2004TheNL,
  title={The new life of a centenarian: signalling functions of NAD(P).},
  author={Felicitas Berger and Mar{\'i}a Helena Ram{\'i}rez-Hern{\'a}ndez and Mathias Ziegler},
  journal={Trends in biochemical sciences},
  year={2004},
  volume={29 3},
  pages={
          111-8
        }
}
View on PubMed
web.archive.org
468 Citations
Highly Influential Citations
19
Background Citations
208
Methods Citations
1

Figures from this paper

468 Citations

The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways.
TLDR
An integrated view on the pathways that control NAD(+) production and cycling, as well as its cellular compartmentalization, and novel data that show how modulation of NAD(+)-producing and -consuming pathways have a major physiological impact and hold promise for the prevention and treatment of metabolic disease are provided.
NAD+ biosynthesis and salvage – a phylogenetic perspective
TLDR
The findings suggest the parallel phylogenetic appearance of Nam N‐methyltransferase, Nam phosphoribosyl transferase, and poly‐ADP‐ribosyltransferases, which have been thought to be mutually exclusive.
Diversification of NAD biological role : the importance of location
TLDR
The known NAD biosynthetic and catabolic pathways are described, and evidence supporting a specialized role for NAD metabolism in a subcellular compartment‐dependent manner is reviewed.
The power to reduce: pyridine nucleotides--small molecules with a multitude of functions.
TLDR
Recent advances in the understanding of the biosynthesis and signalling functions of NAD(P) are summarized and new insights into the molecular mechanisms of NADPH generation and their roles in cell physiology are highlighted.
Pyridine Nucleotide Homeostasis in Plant Development and Stress
TLDR
Levels of these PNs in plant cells show considerable changes during various developmental stages indicating these molecules can serve as metabolic read out of cell fate, indicating the versatility of these labile redox molecules in plant health and sickness is only beginning.
NAD: Metabolism and Regulatory Functions
TLDR
In this chapter the newly recognised NAD-mediated regulatory pathways and the advances in the understanding of NAD biosynthesis will be covered and it will be highlighted that the relationship between PARP1 and NAD synthesis deserves particular attention under conditions of cellular stress involving DNA damage.
NAD+ Biosynthesis and Signaling in Plants
TLDR
A synthesis of a number of molecular genetic studies as well as biochemical analyses that have begun to elucidate the regulatory hierarchies both of NAD+ biosynthesis and the parallel activities of the enzymes that are involved in these pathways are presented.
NAD(P) synthesis and pyridine nucleotide cycling in plants and their potential importance in stress conditions.
TLDR
An overview of the current state of knowledge on NAD synthesis pathways in plants and other organisms is provided, a preliminary model for the intracellular distribution of NAD synthesis is proposed, and plant homologues of recently identified yeast mitochondrial NAD transporters are presented.
NAD biosynthesis in humans--enzymes, metabolites and therapeutic aspects.
TLDR
Targeted nutritional supplementation and exciting therapeutic concepts have emerged, which aim at modulation of NAD availability by interfering with the biosynthetic network to prevent, reduce or reverse pathological conditions.
Structure and function of an ADP-ribose-dependent transcriptional regulator of NAD metabolism.
...
...

References

SHOWING 1-10 OF 76 REFERENCES
Reconstructing eukaryotic NAD metabolism.
TLDR
It is proposed that the development of several NAD biosynthetic routes during evolution has led to partial functional redundancy, allowing a given pathway to freely acquire novel functions unrelated to NAD biosynthesis.
New functions of a long-known molecule. Emerging roles of NAD in cellular signaling.
  • M. Ziegler
  • Biology, Chemistry
    European journal of biochemistry
  • 2000
TLDR
The first group of reactions leads to the synthesis of an unusual cyclic nucleotide, cyclic ADP-ribose (cADPR), which has been reported to be potent intracellular calcium-mobilizing agents and in concert with inositol 1,4,5-trisphosphate, they participate in cytosolic calcium regulation by releasing calcium from intrace cellular stores.
Linking chromatin function with metabolic networks: Sir2 family of NAD(+)-dependent deacetylases.
  • J. Denu
  • Biology, Chemistry
    Trends in biochemical sciences
  • 2003
Structural Characterization of a Human Cytosolic NMN/NaMN Adenylyltransferase and Implication in Human NAD Biosynthesis* 210
TLDR
The characterization of the cytosolic human PNAT-3 provided compelling evidence that the final steps of NAD biosynthesis pathways may exist in mammalian cytoplasm and mitochondria, potentially contributing to their NAD/NADP pool.
Structural and functional characterization of human NAD kinase.
TLDR
A human NAD kinase cDNA was amplified from a human fibroblast cDNA library and functionally overexpressed in Escherichia coli suggesting that the potent calcium-mobilizing pyridine nucleotide NAADP is synthesized by an alternative route.
Enzymology of NAD+ synthesis.
TLDR
This review describes the enzymes involved in pyridine nucleotide metabolism, starting with a detailed consideration of the anaerobic and aerobic pathways leading to quinolinate, a key precursor of NAD+.
Functional aspects of protein mono‐ADP‐ribosylation
TLDR
The intracellular ADP‐ribosyltransferases may be part of a novel protein family with an important role in regulating cell function and providing a mechanism to inhibit protein functions in both physiological and pathological conditions.
Identification of a novel human nicotinamide mononucleotide adenylyltransferase.
Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers.
  • H. C. Lee
  • Biology
    Annual review of pharmacology and toxicology
  • 2001
TLDR
These two novel nucleotides have now been shown to be involved in a wide range of cellular functions including: cell cycle regulation in Euglena, a protist; gene expression in plants; and in animal systems, from fertilization to neurotransmitter release and long-term depression in brain.
Physiology and pathophysiology of poly(ADP‐ribosyl)ation *
  • A. Bürkle
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2001
TLDR
Physiological functions include its participation in DNA‐base excision repair, DNA‐damage signalling, regulation of genomic stability, and regulation of transcription and proteasomal function, supporting the previously observed correlation of cellular poly(ADP‐ribosyl)ation capacity with mammalian life.
...
...