The new generation of monoamine oxidase inhibitors.

  title={The new generation of monoamine oxidase inhibitors.},
  author={Andrea M Cesura and Alfred Pletscher},
  journal={Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques},
Irreversible and unspecific inhibitors of MAO were the first modern antidepressants, but after an initial success they fell into discredit due to adverse side effects. In the past two decades interest in MAO inhibitors has been renewed because of progress in basic research, a milestone being the finding that there are two subtypes of MAO, MAO-A and MAO-B. These are distinct proteins with high amino acid homology, coded by separate genes both located on the short arm of the human chromosome X… CONTINUE READING