The new facile and straightforward method for the synthesis of 4H-1,2,3-thiadiazolo[5,4-b]indoles and determination of their antiproliferative activity.

Abstract

A series of 4H-1,2,3-thiadiazolo[5,4-b]indoles were synthesized by novel tandem of oxidative cyclization of 3-alkoxycarbonylhydrazonoindoline-2-thiones, 1,5-H-shift and elimination of tert-butoxy(ethoxy)carbonyl group. The simple method for their modifications by the reactions with electrophilic agents were elaborated and as a result of the synthetic… (More)
DOI: 10.1016/j.ejmech.2015.11.011

Topics

11 Figures and Tables

Cite this paper

@article{Belskaya2016TheNF, title={The new facile and straightforward method for the synthesis of 4H-1,2,3-thiadiazolo[5,4-b]indoles and determination of their antiproliferative activity.}, author={Nataliya P Belskaya and Kseniya I Lugovik and Vasiliy A Bakulev and Jenny Bauer and Igor Kitanovic and Pavlo Holenya and Maxim V Zakhartsev and Stefan W{\"o}lfl}, journal={European journal of medicinal chemistry}, year={2016}, volume={108}, pages={245-257} }