The new compound GET73, N-[(4-trifluoromethyl)benzyl]4-methoxybutyramide, Regulates hippocampal Aminoacidergic transmission possibly via an allosteric modulation of mGlu5 receptor. Behavioural evidence of its "anti-alcohol" and anxiolytic properties.

@article{Ferraro2013TheNC,
  title={The new compound GET73, N-[(4-trifluoromethyl)benzyl]4-methoxybutyramide, Regulates hippocampal Aminoacidergic transmission possibly via an allosteric modulation of mGlu5 receptor. Behavioural evidence of its "anti-alcohol" and anxiolytic properties.},
  author={Luca Ferraro and Antonella Loche and Sarah Beggiato and Maria Cristina Tomasini and Tiziana Antonelli and Giancarlo Colombo and Carla Lobina and Mauro A. M. Carai and Alessandra Porcu and Maria Paola Castelli and Francesca Clerici and Andrea Celeste Borelli and Roberto Cacciaglia and Sergio Tanganelli},
  journal={Current medicinal chemistry},
  year={2013},
  volume={20 27},
  pages={
          3339-57
        }
}
The present article attempts to provide, on the basis of data emerging from studies carried out in our laboratories, a summary of the chemical and pharmacological properties of the new compound N-[(4-trifluoromethyl)benzyl]4- methoxybutyramide (GET73). Particular emphasis is given to findings obtained in vivo and in vitro suggesting that an allosteric modulation of metabotropic glutamate receptor 5 (mGlu5 receptor) by GET73 may represent the mechanism underlying the effects of the compound… CONTINUE READING