The new biology of gastrointestinal hormones.

  title={The new biology of gastrointestinal hormones.},
  author={Jens F Rehfeld},
  journal={Physiological reviews},
  volume={78 4},
  • J. Rehfeld
  • Published 1 October 1998
  • Biology
  • Physiological reviews
The classic concept of gastrointestinal endocrinology is that of a few peptides released to the circulation from endocrine cells, which are interspersed among other mucosal cells in the upper gastrointestinal tract. Today more than 30 peptide hormone genes are known to be expressed throughout the digestive tract, which makes the gut the largest endocrine organ in the body. Moreover, development in cell and molecular biology now makes it feasible to describe a new biology for gastrointestinal… 

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