The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells.

@article{Rundfeldt1997TheNA,
  title={The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells.},
  author={Chris Rundfeldt},
  journal={European journal of pharmacology},
  year={1997},
  volume={336 2-3},
  pages={243-9}
}
The patch-clamp technique was used to measure currents passing through K+ channels in neuronal cell preparations. Retigabine (D-23129, N-(2-amino-4-(4-fluorobenzylamino)-phenyl) carbamic acid ethyl ester) activated a K+ conductance in slightly depolarized NG108-15 neuronal cells in a dose-dependent manner (0.1-10 microM). At the K+ reversal potential, no current could be elicited and in hyperpolarized cells the current was reversed. A similar current was elicited in primary cultures of mouse… CONTINUE READING

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