The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes

@article{Magne2006TheNI,
  title={The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes},
  author={David Magne and Gaby Palmer and Jenny L Barton and Françoise M{\'e}zin and Dominique Talabot-Ayer and Sylvette Bas and Trevor Duffy and Marcus Noger and P. A. Guerne and Martin J H Nicklin and Cem Gabay},
  journal={Arthritis Research & Therapy},
  year={2006},
  volume={8},
  pages={R80 - R80}
}
Six novel members of the IL-1 family of cytokines were recently identified, primarily through the use of DNA database searches for IL-1 homologues, and were named IL-1F5 to IL-1F10. In the present study, we investigated the effect of IL-1F8 on primary human joint cells, and examined the expression of the new IL-1 family members in human and mouse joints. Human synovial fibroblasts (hSFs) and human articular chondrocytes (hACs) expressed the IL-1F8 receptor (IL-1Rrp2) and produced pro… CONTINUE READING

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