The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140.

@article{Picker1991TheNS,
  title={The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140.},
  author={Louis J. Picker and Richard A. Warnock and Alan R. Burns and Claire M Doerschuk and Ellen Lakey Berg and Eugene C. Butcher},
  journal={Cell},
  year={1991},
  volume={66 5},
  pages={921-33}
}
LECAM-1 (leukocyte-endothelial cell adhesion molecule 1), the lymphocyte lectin ("selectin") homing receptor for peripheral lymph nodes (PLNs), participates in the earliest interactions of polymorphonuclear neutrophilic leukocytes (PMNs) with inflamed venules. Here, we present evidence that LECAM-1 mediates this function through a novel mechanism--presentation of oligosaccharide ligands to the inducible vascular selectins endothelial-leukocyte adhesion molecule (ELAM-1) and granule membrane… CONTINUE READING
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