The neutrophil recombinatorial TCR-like immune receptor is expressed across the entire human life span but repertoire diversity declines in old age.

@article{Fuchs2012TheNR,
  title={The neutrophil recombinatorial TCR-like immune receptor is expressed across the entire human life span but repertoire diversity declines in old age.},
  author={Tina Fuchs and Kerstin P{\"u}ellmann and Olivia Scharfenstein and Romy Eichner and Elfi Stobe and Anna Becker and Ioanna Pechlivanidou and Julia G. Kzhyshkowska and Alexei Gratchev and Arnold Ganser and Michael Neumaier and Alexander W. Beham and W E Kaminski},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={419 2},
  pages={309-15}
}
Recent evidence has revealed the existence of T cell receptor (TCR) αβ-based recombinatorial immune receptors in phagocytes. Here, we performed a systematic survey of the variable β-chain repertoires of the neutrophil TCR-like αβ immunoreceptor (referred to as TCRL(n)αβ) in defined cohorts of young and old individuals. Peripheral blood CD15(+) neutrophils from young adults (age 30 ± 7 years, n=12) expressed an average number of 13 ± 6 distinct TCRL(n) Vβ-chains from the total pool of 25 human V… CONTINUE READING