The neutrophil in antineutrophil cytoplasmic autoantibody-associated vasculitis.

  title={The neutrophil in antineutrophil cytoplasmic autoantibody-associated vasculitis.},
  author={Adrian Schreiber and Ralph Kettritz},
  journal={Journal of leukocyte biology},
  volume={94 4},
Necrotizing, small-vessel vasculitis develops in patients with circulating ANCAs. Neutrophils and monocytes harbor the two major ANCA antigens, PR3 and MPO. A whole body of in vitro experiments implicated ANCA-activated neutrophil effector functions in the pathogenesis of vasculitis, whereas the role of monocytes is less well-characterized. Mouse models for anti-MPO-induced vasculitis were developed to study ANCA-neutrophil interactions in complex in vivo situations. We not only discuss the… CONTINUE READING

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