The neutrophil-activating protein of Helicobacter pylori down-modulates Th2 inflammation in ovalbumin-induced allergic asthma.

@article{Codolo2008TheNP,
  title={The neutrophil-activating protein of Helicobacter pylori down-modulates Th2 inflammation in ovalbumin-induced allergic asthma.},
  author={Gaia Codolo and Paola Mazzi and Amedeo Amedei and Gianfranco Del Prete and Giorgio Berton and Mario Milco D'Elios and Marina de Bernard},
  journal={Cellular microbiology},
  year={2008},
  volume={10 11},
  pages={2355-63}
}
The Helicobacter pylori neutrophil-activating protein (HP-NAP) is able in vitro to elicit IL-12 and IL-23 production via agonistic interaction with toll-like receptor 2, and to promote Th1 polarization of allergen-specific T-cell responses. This study was aimed to assess whether systemic/intraperitoneal and/or mucosal HP-NAP administration inhibited the Th2-mediated bronchial inflammation using a mouse model of allergic asthma induced by inhaled ovalbumin (OVA). Systemic HP-NAP delivery… CONTINUE READING
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