The neurotrophins and their receptors.

  title={The neurotrophins and their receptors.},
  author={D J Glass and George D. Yancopoulos},
  journal={Trends in cell biology},
  volume={3 8},
The neurotrophins, which include nerve growth factor (NGF) and its relatives, were discovered and characterized for their distinctive ability to promote survival and differentiation of postmitotic neurons. Perhaps surprisingly, the neurotrophins have recently been found to utilize a family of receptor tyrosine kinases (the Trks) similar to those used by normally mitogenic growth factors. In fact, ectopic expression of the Trks in non-neuronal cells allows them to mediate conventional mitogenic… CONTINUE READING

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