The neurotrophic theory and naturally occurring motoneuron death

@article{Oppenheim1989TheNT,
  title={The neurotrophic theory and naturally occurring motoneuron death},
  author={Ronald W Oppenheim},
  journal={Trends in Neurosciences},
  year={1989},
  volume={12},
  pages={252-255}
}
  • R. Oppenheim
  • Published 31 December 1989
  • Medicine, Biology
  • Trends in Neurosciences
There is increasing evidence that target-derived molecules play a crucial role in the regulation of neuronal survival during development. These molecules, termed neurotrophic factors, are thought to act in specific ways as defined by the neurotrophic theory. One central tenet of the neurotrophic theory is that some neurons in a population die because trophic molecules are available in only limited amounts during periods of naturally occurring cell death. Delivery of trophic factor to nerve… 
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