The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

@article{Soppet1991TheNF,
  title={The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor},
  author={D. Soppet and E. Escand{\'o}n and Johnne Maragos and D. Middlemas and Susan W. Raid and Janet Blair and L. Burton and B. Stanton and D. Kaplan and T. Hunter and K. Nikolics and Luis F. Parade},
  journal={Cell},
  year={1991},
  volume={65},
  pages={895-903}
}
Neurotrophic factors are essential for neuronal survival and function. Recent data have demonstrated that the product of the tyrosine kinase trk proto-oncogene binds NGF and is a component of the high affinity NGF receptor. Analysis of the trkB gene product, gp145trkB, in NIH 3T3 cells indicates that this tyrosine kinase receptor is rapidly phosphorylated on tyrosine residues upon exposure to the NGF-related neurotrophic factors BDNF and NT-3. Furthermore, gp145trkB specifically binds BDNF and… Expand
Analysis of the trk NGF receptor tyrosine kinase using recombinant fusion proteins
TLDR
Comparative crosslinking indicates that NGF can recognize all trk receptor members, illustrating the large number of potential ligand-receptor interactions between neurotrophins and their receptors. Expand
The Trk family of neurotrophin receptors.
  • M. Barbacid
  • Biology, Medicine
  • Journal of neurobiology
  • 1994
TLDR
Preliminary characterization of these mutant mice has provided significant information regarding the role of these receptors in the ontogeny of the mammalian nervous system, and TrkC-deficient mice display strikingly abnormal movements consistent with loss of proprioception. Expand
The nerve growth factor receptor: a multicomponent system that mediates the actions of the neurotrophin family of proteins
Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 3 (NT-3) are members of a family of structurally related proteins termed neurotrophins that promote the growthExpand
Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB
TLDR
NT-5 is structurally related to nerve growth factor and is expressed in embryonic as well as adult tissues and promotes the survival of peripheral sensory and sympathetic neurons and induces differentiation of the pheochromocytoma cell line PC12. Expand
The trkB tyrosine protein kinase is a receptor for neurotrophin-4
TLDR
XNT-4 and BDNF may interact with at least partially distinct domains within the gp145trkB receptor, a murine tyrosine protein kinase previously identified as a primary receptor for the related brain-derived neurotrophic factor (BDNF). Expand
Brain-derived Neurotrophic Factor Induces Phosphorylation of Fibroblast Growth Factor Receptor Substrate 2*
TLDR
Data is presented demonstrating that BDNF induces association of FRS2 with growth factor receptor-binding protein 2 (GRB2) in cortical neurons, fibroblasts, and NB cells, which in turn could activate the RAS/MAPK pathway and suggest that FRS 2 and suc-associated neurotrophic factor-induced tyrosine-phosphorylated target are the same protein. Expand
p75 and Trk: A two-receptor system
TLDR
Evidence indicates that co-expression of the two genes for the p75 receptor and the Trk NGF receptor can potentially lead to greater responsiveness to NGF, and suggests additional levels of regulation for the family of neurotrophin factors. Expand
Receptors and signaling pathways of ciliary neurotrophic factor and the neurotrophins
TLDR
Although the neurotrophin and CNTF receptor systems differ drastically, they display certain parallels and both depend on ligand-induced dimerization of signal transducing receptor components to activate signaling. Expand
Neuronal life and death decisions: functional antagonism between the Trk and p75 neurotrophin receptors
  • M. Majdan, F. Miller
  • Biology, Medicine
  • International Journal of Developmental Neuroscience
  • 1999
TLDR
Questions are raised about the mechanisms whereby the neurotrophins mediate neuronal life versus death and the biological rationale for having one class of growth factors Int. Expand
Neurotrophins and their Receptors
TLDR
Using this approach, NGF has been shown to expert a trophic stimulation for cholinergic neurons in the brain and BDNF and its receptor could, in a paracrine/autocrine fashion, play a role in kindling-associated neural plasticity and in neuronal protection following ischemic and hypoglycemic insults. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 52 REFERENCES
Neurotrophin-3: a neurotrophic factor related to NGF and BDNF.
TLDR
The distribution of NT-3 messenger RNA and its biological activity on a variety of neuronal populations clearly distinguishNT-3 from NGF and BDNF, and provide compelling evidence that NT- 3 is an authentic neurotrophic factor that has its own characteristic role in vivo. Expand
Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF
TLDR
Tyrosine phosphorylation of trk by NGF is rapid, specific and occurs with picomolar quantities of factor, indicating that the response is mediated by physiological amounts of NGF. Expand
Binding of brain-derived neurotrophic factor to the nerve growth factor receptor
TLDR
It is found that a 1000-fold excess of the heterologous ligand is needed to reduce binding to the high-affinity receptor by 50%, but that the same concentrations of BDNF and NGF similarly reduce the binding of either ligand to the low-Affinity receptor. Expand
Binding characteristics of brain-derived neurotrophic factor to its receptors on neurons from the chick embryo
Brain-derived neurotrophic factor (BDNF), a protein known to support the survival of embryonic sensory neurons and retinal ganglion cells, was derivatized with 125I-Bolton-Hunter reagent and obtainedExpand
Primary structure and biological activity of human brain-derived neurotrophic factor.
TLDR
Brain-derived neurotrophic factor has been shown to promote the survival of neurons located in or directly connected with the CNS and is likely to function in adjusting the cell number within neuronal populations to the need of this projection field. Expand
NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression
TLDR
The observations are consistent with the idea that NT-3, BDNF, and NGF have paralleled as well as reciprocal roles in vivo, and do share one striking similarity--high level expression in the adult hippocampus. Expand
Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family
TLDR
Taking advantage of sequence identities between NGF and BDNF, a third member of this family of secretory proteins is identified, which is named neurotrophin-3, and a remarkable number of amino acid identities are revealed, including all cys-teine residues. Expand
The trk proto-oncogene product: a signal transducing receptor for nerve growth factor.
TLDR
Affinity cross-linking and equilibrium binding experiments with 125I-labeled NGF indicate that p140prototrk binds NGF specifically in cultured cells with a dissociation constant of 10(-9) molar. Expand
The trk proto-oncogene encodes a receptor for nerve growth factor
TLDR
The results indicate that gp140trk is a functional NGF receptor that mediates at least some of the signal transduction processes initiated by this neurotrophic factor. Expand
Molecular cloning of a human gene that is a member of the nerve growth factor family.
  • K. Jones, L. Reichardt
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1990
Cell death within the developing vertebrate nervous system is regulated in part by interactions between neurons and their innervation targets that are mediated by neurotrophic factors. These factorsExpand
...
1
2
3
4
5
...