The neurotrophic factor neuroleukin is 90% homologous with phosphohexose isomerase

@article{Chaput1988TheNF,
  title={The neurotrophic factor neuroleukin is 90\% homologous with phosphohexose isomerase},
  author={Mariella Chaput and Victor Claes and Daniel Portetelle and Isabelle Cludts and Alfredo Cravador and Ars{\`e}ne Burny and H{\'e}l{\`e}ne Gras and Andr{\'e} L Tartar},
  journal={Nature},
  year={1988},
  volume={332},
  pages={454-455}
}
Neuroleukin (NLK) is a protein of relative molecular mass (Mr) 56,000 (56K) secreted by denervated rat muscle1 and found in large amounts in muscle, brain, heart and kidneys2. The protein is a neurotrophic factor for spinal and sensory neurons2 and a lymphokine product of lectin-stimulated T-cells3. It also induces immunoglobulin secretion by human mononuclear cells3. Molecular clones of NLK have been expressed in monkey COS cells and the product was shown to have the same biological and… 
Mouse glucose-6-phosphate isomerase and neuroleukin have identical 3′ sequences
TLDR
It is reported here that there is complete sequence identity between the 759 nucleotides at the 3′ end of this clone (coding and non-coding) and the sequence of mouse neuroleukin.
Expression of the AMF/neuroleukin receptor in developing and adult brain cerebellum
TLDR
Data indicate that regulation of the neurotrophic function of neuroleukin might be regulated spatially and temporally by expression of its receptor, AMF‐R, in developing and adult cerebellum.
Expression and secretion of neuroleukin/phosphohexose isomerase/maturation factor as autocrine motility factor by tumor cells.
TLDR
The results suggest that extracellular AMF activity may be a result of the product of intracellular cleavage of a precursor polypeptide, which is overexpressed and selectively secreted through a nonclassical secretory mechanism by neoplastic cells.
Tumor cell autocrine motility factor is the neuroleukin/phosphohexose isomerase polypeptide.
TLDR
The results demonstrate that AMF is the previously cloned cytokine and enzyme designated as neuroleukin, and phosphohexose isomerase (PHI), which has been independently implicated in cell motility, and to be a cancer progression marker.
Expression and Secretion of Neuroleukin / Phosphohexose Isomerase / Maturation Factor as Autocrine Motility Factor by Tumor Cells 1
TLDR
The results suggest that extracellular AMF activity may be a result of the product of intracellular cleavage of a precursor polypeptide, which is overexpressed and selec tively secreted through a nonclassical secretory mechanism by neoplastic cells.
Purification and Characterization of Phosphohexose Isomerase from Human Gastrointestinal Carcinoma and Its Potential Relationship to Neuroleukin1
TLDR
The results obtained support the hypothesis that three PHI variants derived from human gastrointestinal tumor tissue are due to a specific intracellular cleavage of the enzyme in the malignant cells.
Neuronal Survival Factor from Bovine Brain Is Identical to Neuron‐Specific Enolase
TLDR
Highly purified NSE supported the survival of cultured neurons in a dose‐dependent manner, and the neurotrophic effect was inhibited by monoclonal antibody to the NSE.
Purification and characterization of phosphohexose isomerase from human gastrointestinal carcinoma and its potential relationship to neuroleukin.
TLDR
The results obtained support the hypothesis that three PHI variants derived from human gastrointestinal tumor tissue are due to a specific intracellular cleavage of the enzyme in the malignant cells.
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References

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Molecular cloning and expression of neuroleukin, a neurotrophic factor for spinal and sensory neurons.
TLDR
A novel 56,000-dalton growth factor found in mouse salivary gland was purified, molecularly cloned, and expressed in monkey COS cells, and the factor was named neuroleukin, a neurotrophic factor and also a lymphokine product of lectin-stimulated T cells.
Functional interaction and partial homology between human immunodeficiency virus and neuroleukin.
TLDR
The inhibition by HIV-1 of neuron growth in the presence of NLK was found to be due to the gp120 envelope glycoprotein, and regions of sequence homology between gp120 and NLK may account for this inhibitory property of gp120.
Neuroleukin: a lymphokine product of lectin-stimulated T cells.
TLDR
Neuroleukin is a lymphokine product of lectin-stimulated T cells that induces immunoglobulin secretion by cultured human peripheral blood mononuclear cells that is both monocyte- and T-cell-dependent.
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TLDR
A tentative fit of two of the peptides to the electron density map has been made and it seems possible that glucose-6-phosphate isomerase, triose phosphate isomersase and pyruvate kinase all contain a histidine and a glutamate residue at the active site.
Suppression of sprouting at the neuromuscular junction by immune sera
TLDR
Rabbit antisera against a 56,000 (56K)-molecular weight protein secreted by denervated rat muscle suppress botulinum toxin-induced terminal sprouting in the mouse gluteus muscle, detecting an immune response against this protein in patients with amyotrophic lateral sclerosis.
Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs.
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  • Biology
    Nucleic acids research
  • 1984
TLDR
The sequence CCAGCCAUG (G) thus emerges as a consensus sequence for eukaryotic initiation sites, and the extent to which the ribosome binding site in a given mRNA matches the -1 to -5 consensus sequence varies.