The neurosteroids progesterone and allopregnanolone reduce cell death, gliosis, and functional deficits after traumatic brain injury in rats.

@article{Djebaili2005TheNP,
  title={The neurosteroids progesterone and allopregnanolone reduce cell death, gliosis, and functional deficits after traumatic brain injury in rats.},
  author={M Karim Djebaili and Qingmin Guo and Edward H. Pettus and Stuart W. Hoffman and Donald G. Stein},
  journal={Journal of neurotrauma},
  year={2005},
  volume={22 1},
  pages={106-18}
}
This report compares the effects of progesterone and its metabolite, allopregnanolone, on the early injury cascade (apoptosis) and long-term functional deficits after TBI. Progesterone (16 mg/kg) or allopregnanolone (4, 8, or 16 mg/kg) were injected at 1 h, 6 h, and then for 5 consecutive days after bilateral contusions of the frontal cortex in adult male rats. Within one day after injury, progesterone and allopregnanolone reduced both the expression of pro-apoptotic proteins caspase-3 and Bax… CONTINUE READING
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