The neurosteroid pregnanolone prevents the anxiogenic-like effect of inescapable shock in the rat

@article{Bitran2000TheNP,
  title={The neurosteroid pregnanolone prevents the anxiogenic-like effect of inescapable shock in the rat},
  author={Daniel Bitran and David A. Klibansky and Gina A. Martin},
  journal={Psychopharmacology},
  year={2000},
  volume={151},
  pages={31-37}
}
Rationale and objectives: The ability of progesterone (P4) and its neurosteroid metabolite, 3α-OH-5β-pregnan-20-one (pregnanolone) in protecting against the anxiogenic-like effect of inescapable shock (IS) in male rats was examined, as these steroids exert anxiolytic, anticonvulsant, and ataxic effects similar to the benzodiazepines (BZ), drugs shown to prevent IS-induced anxiogenesis. Methods: Adult male rats were injected with pregnanolone (8 mg/kg, SC), P4 (4 mg/rat) or its appropriate… CONTINUE READING

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