The neurosteroid allopregnanolone increases dopamine release and dopaminergic response to morphine in the rat nucleus accumbens

  title={The neurosteroid allopregnanolone increases dopamine release and dopaminergic response to morphine in the rat nucleus accumbens},
  author={Françoise Rougé-Pont and Willy Mayo and Michela Micky Marinelli and Mireille A Gingras and Michel Le Moal and Pier Vincenzo Piazza},
  journal={European Journal of Neuroscience},
Neurosteroids are a subclass of steroids that can be synthesized in the central nervous system independently from peripheral sources. Clinical studies in humans have associated these hormones with depression and postpartum mood disorders. In rodents, allopregnanolone (AlloP) has been shown to have anxiolytic and rewarding properties. These observations suggest that neurosteroids could interact with mood and motivation. However, the possible neural substrates of these effects remain unknown. In… 

Allopregnanolone Decreases Evoked Dopamine Release Differently in Rats by Sex and Estrous Stage

Allopregnanolone reduces evoked dopamine release in both male and female rats and extends the knowledge about the pharmacological effects of neurosteroids on dopamine transmission, which may contribute to their therapeutic effects.

Dopamine is involved in the antidepressant-like effect of allopregnanolone in the forced swimming test in female rats

The present results indicate an involvement of dopamine transmission in the allopregnanolone antidepressant-like effect in the forced swimming model of depression, and suggest that this effect depends mainly on stimulation of dopamine D2-like receptors.

Neurosteroids in nicotine and morphine dependence

Changes in neurosteroid concentrations mediated by activation of the HPA axis may both contribute to the early acquisition phase of nicotine or morphine addiction and serve to counteract the anxiety-like behavior associated with Nicotine or morphine withdrawal.

Relating neurosteroid modulation of inhibitory neurotransmission to behaviour

How neurosteroids acting upon GABAARs influence neuronal signalling, as well as how such effects may acutely and persistently influence behaviour, are considered and the case for developing selective PAMs of δ‐GABAAR subtypes for the treatment of psychiatric disorders is explored.

Multifunctional aspects of allopregnanolone in stress and related disorders

  • Anjana BaliA. Jaggi
  • Biology, Medicine
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2014

Effects of the neuroactive steroid allopregnanolone on intracranial self-stimulation in C57BL/6J Mice

The effects of allopregnanolone on BSR thresholds are consistent with the previously reported effects of benzodiazepines and alcohol, suggesting that positive modulation of GABAA receptors can facilitate reward-related behaviors in C57BL/6J mice.

Neurosteroids and GABAA Receptor Interactions: A Focus on Stress

How brain-derived neurosteroids may impact on the stress response to acute and chronic challenges, both pre- and postnatally through to adulthood are critically appraised.



The neurosteroid pregnenolone sulphate increases dopamine release and the dopaminergic response to morphine in the rat nucleus accumbens

The action of Preg‐S on the activity of the mesencephalic dopaminergic projection to the nucleus accumbens is studied which is considered one of the biological substrates of motivation and reward.

Neurosteroids and reward: allopregnanolone produces a conditioned place aversion in rats

Inhibition of basal and stress-induced dopamine release in the cerebral cortex and nucleus accumbens of freely moving rats by the neurosteroid allopregnanolone

The results suggest that endogenous neurosteroids may participate in the GABAergic modulation of dopaminergic transmission in the rat cerebral cortex and nucleus accumbens, two brain areas which are important in the regulation of emotional processes.

Modulation of A10 dopamine neurons by gamma-aminobutyric acid agonists.

Pretreatment with baclofen prevented the capacity of a mu opioid agonist to elevate dopamine metabolite levels in the nucleus accumbens and prefrontal cortex in postmortem tissue, and supported electrophysiological studies suggesting that activation of gamma-aminobutyric acidB receptors on dopamine perikarya inhibits dopaminergic activity.

Regulation of somatodendritic dopamine release in the ventral tegmental area by opioids and GABA: an in vivo microdialysis study

The present results support a hypothesis that stimulation of mu-opioid or GABAA receptors inhibits the activity of GABAergic afferents to dopamine neurons, thereby removing tonic inhibitory regulation, whereas stimulation of GABAB receptors directly inhibits dopamine neurons.

Modulation of Brain Dopamine Transmission by Sex Steroids

  • T. Di Paolo
  • Biology, Psychology
    Reviews in the neurosciences
  • 1994
A better understanding of steroid-dopamine interactions and the possible isolation of conditions to have only pro or anti dopaminergic activity could then be used to develop combined therapies or to optimize drug treatments that would take into account the patient's sex and endocrine status.

Nucleus accumbens dopamine release modulation by mesolimbic GABAA receptors—an in vivo electrochemical study

GABAA Receptor Blockade in the Anterior Ventral Tegmental Area Increases Extracellular Levels of Dopamine in the Nucleus Accumbens of Rats

The results suggest that DA neurons projecting from the anterior VTA to the ACB are tonically inhibited by GABA through its actions at the GABAA receptors.

Neurosteroids: of the nervous system, by the nervous system, for the nervous system.

  • E. Baulieu
  • Biology, Medicine
    Recent progress in hormone research
  • 1997
A physiological function of neurosteroids in the central nervous system is strongly suggested by the role of hippocampal PREGS with respect to memory, observed in aging rats, and it may be important to study the effect of abnormal neurosteroid concentrations/metabolism with a view to the possible treatment of functional and trophic disturbances of the nervous system.