The neurosteroid allopregnanolone increases dopamine release and dopaminergic response to morphine in the rat nucleus accumbens

@article{RougePont2002TheNA,
  title={The neurosteroid allopregnanolone increases dopamine release and dopaminergic response to morphine in the rat nucleus accumbens},
  author={Françoise Rougé-Pont and Willy Mayo and Michela Micky Marinelli and Mireille A Gingras and Michel Le Moal and Pier Vincenzo Piazza},
  journal={European Journal of Neuroscience},
  year={2002},
  volume={16}
}
Neurosteroids are a subclass of steroids that can be synthesized in the central nervous system independently from peripheral sources. Clinical studies in humans have associated these hormones with depression and postpartum mood disorders. In rodents, allopregnanolone (AlloP) has been shown to have anxiolytic and rewarding properties. These observations suggest that neurosteroids could interact with mood and motivation. However, the possible neural substrates of these effects remain unknown. In… 

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How brain-derived neurosteroids may impact on the stress response to acute and chronic challenges, both pre- and postnatally through to adulthood are critically appraised.
...

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