The neurosteroid allopregnanolone increases dopamine release and dopaminergic response to morphine in the rat nucleus accumbens

  title={The neurosteroid allopregnanolone increases dopamine release and dopaminergic response to morphine in the rat nucleus accumbens},
  author={F. Roug{\'e}-Pont and W. Mayo and M. Marinelli and M. Gingras and M. Le Moal and P. Piazza},
  journal={European Journal of Neuroscience},
  • F. Rougé-Pont, W. Mayo, +3 authors P. Piazza
  • Published 2002
  • Chemistry, Medicine
  • European Journal of Neuroscience
  • Neurosteroids are a subclass of steroids that can be synthesized in the central nervous system independently from peripheral sources. Clinical studies in humans have associated these hormones with depression and postpartum mood disorders. In rodents, allopregnanolone (AlloP) has been shown to have anxiolytic and rewarding properties. These observations suggest that neurosteroids could interact with mood and motivation. However, the possible neural substrates of these effects remain unknown. In… CONTINUE READING
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