The neuropsychiatry of Gilles de la Tourette syndrome: The état de l'art.

  title={The neuropsychiatry of Gilles de la Tourette syndrome: The {\'e}tat de l'art.},
  author={Andrea Eugenio Cavanna},
  journal={Revue neurologique},
  volume={174 9},
  • A. Cavanna
  • Published 8 August 2018
  • Psychology, Medicine
  • Revue neurologique
Gilles de la Tourette syndrome: An overview
A better understanding of the mechanisms at the root of tic production can pave the way to the development of more effective treatment interventions for patients with GTS in order to improve their health-related quality of life (QOL).
The cognitive neuropsychiatry of Tourette syndrome
A narrative review of the recent literature on the cognitive neuropsychiatry of Tourette syndrome suggested that a more precise characterisation of TS phenotypes, including cognitive aspects, will result in improved levels of care for patients with tic disorders.
Relaxation therapy as a treatment for tics in patients with Tourette syndrome: a systematic literature review
Initial evidence for the use of relaxation therapy as a behavioural treatment intervention for tics in patients with TS is provided, although caution is needed in the interpretation of these findings, because the reviewed trials had small sample sizes and there was high heterogeneity across the study protocols.
Altered sense of agency in Gilles de la Tourette syndrome: behavioural, clinical and functional magnetic resonance imaging findings
Evidence is found of an impaired sense of agency in Tourette syndrome patients who, as a group, did not show a significant intentional binding, and this may lead to difficulties in distinguishing external consequences produced by their own actions from the ones caused by others in Tourett syndrome patients.
Ticked Off: Anger Outbursts and Aggressive Symptoms in Tourette Disorder.
Cross-cultural adaptation and psychometric evaluation of the French version of the Gilles de la Tourette Syndrome Quality of Life Scale (GTS-QOL)
The cross-cultural adaptation and validation of this specific instrument will make it possible to assess health-related quality of life in French-speaking subjects with GTS and provide evidence of the good psychometric properties of the GTS-QOL-French.
Neuropsychiatric Aspects of Impulse Control Disorders.
Pharmacological Treatment of Tics
Providing an overview of the assessment, diagnosis, and pharmacological treatment of tics, this is a practical handbook designed for use in busy clinics by trainees and practitioners in a range of
Motor stereotypies in adult patients with Tourette syndrome
This research presents a novel and scalable approach to personalized medicine that addresses the central nervous system’s barriers to effective treatment of obsessive-compulsive disorder.


The Semiology of Tics, Tourette's, and Their Associations
A comprehensive update on the multifarious aspects of the movement disorder and neuropsychiatry of GTS is provided and available treatment options are commented on.
Gilles de la Tourette syndrome
Future research that integrates clinical and neurobiological data, including neuroimaging and genetics, is expected to reveal the pathogenesis of GTS at the neural circuit level, which may lead to targeted interventions.
The psychopathological spectrum of Gilles de la Tourette syndrome
The effects of Gilles de la Tourette syndrome and other chronic tic disorders on quality of life across the lifespan: a systematic review
QoL profiles in children often reflect the impact of co-morbid attention-deficit and hyperactivity symptoms, which tend to improve with age, whereas adults’ perception of QoL seems to be more strongly affected by the presence of depression and anxiety.
Trials of Pharmacological Interventions for Tourette Syndrome: A Systematic Review
The alpha-2 agonist Clonidine is amongst the agents with the most favourable efficacy-versus-adverse events ratio, especially in patients with co-morbid attention-deficit hyperactivity disorder, although effect sizes vary evidence-based studies.
Tics and tourette syndrome.
The prognosis of Tourette syndrome: implications for clinical practice.
It is suggested that tic frequency and severity decline with age in a large proportion of patients (59-85%) and predictors of increased tic severity in adulthood include higher childhood tics severity, smaller caudate volumes and poorer fine motor control.
Health-Related Quality of Life in Gilles de la Tourette Syndrome: A Decade of Research
This review focuses on the current evidence on the impact of GTS on patients' lives, mainly informed by studies using generic functional impairment and HR-QOL measures from the last decade, and expands on the new opportunities introduced by the recently developed GTS-specific HR- QOL scales.
Aripiprazole Improves Associated Comorbid Conditions in Addition to Tics in Adult Patients with Gilles de la Tourette Syndrome
Evidence is provided that patients' decision making process for or against medical treatment is influenced by other factors than tic severity and QoL, which suggests that aripiprazole may improve associated comorbid conditions in addition to tics in patients with GTS.