The neuroprotective effect of pituitary adenylate cyclase-activating polypeptide on cerebellar granule cells is mediated through inhibition of the CED3-related cysteine protease caspase-3/CPP32.

@article{Vaudry2000TheNE,
  title={The neuroprotective effect of pituitary adenylate cyclase-activating polypeptide on cerebellar granule cells is mediated through inhibition of the CED3-related cysteine protease caspase-3/CPP32.},
  author={David Vaudry and Bruno J. Gonzalez and Magali Basille and Tommy F. Pamantung and Marc Fontaine and Alain Fournier and Hubert Vaudry},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 24},
  pages={13390-5}
}
Caspase-3 knockout mice exhibit thickening of the internal granule cell layer of the cerebellum. Concurrently, it has been shown that intracerebral injection of pituitary adenylate cyclase-activating polypeptide (PACAP) induces a transient increase of the thickness of the cerebellar cortex. In the present study, we have investigated the possible effect of PACAP on caspase activity in cultured cerebellar granule cells from 8-day-old rat. Incubation of granule neurons with PACAP for 24 h promoted… CONTINUE READING

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