The neuroprotective effect of inflammation: implications for the therapy of multiple sclerosis.

@article{Hohlfeld2000TheNE,
  title={The neuroprotective effect of inflammation: implications for the therapy of multiple sclerosis.},
  author={Reinhard Hohlfeld and Martin Kerschensteiner and Christine Stadelmann and Hans Lassmann and Hartmut Wekerle},
  journal={Journal of neuroimmunology},
  year={2000},
  volume={107 2},
  pages={
          161-6
        }
}
Autoreactive T cells are a component of the normal immune system. It has been proposed that some of these autoreactive T cells even have a protective function. Recent studies support this notion by demonstrating that (a) myelin basic-protein (MBP-) specific T cells show neuroprotective effects in vivo, and (b) activated antigen-specific human T cells and other immune cells produce bioactive brain-derived neurotrophic factor (BDNF) in vitro. Furthermore, BDNF is expressed in different types of… CONTINUE READING

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