The neuroprotective and angiogenesis inhibitory serpin, PEDF: new insights into phylogeny, function, and signaling.

@article{TombranTink2005TheNA,
  title={The neuroprotective and angiogenesis inhibitory serpin, PEDF: new insights into phylogeny, function, and signaling.},
  author={Joyce Tombran-Tink},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2005},
  volume={10},
  pages={2131-49}
}
Pigment Epithelial-Derived Factor (PEDF) is a non inhibitory serpin with neuroprotective and antiangiogenic actions. It is a potent and broadly acting neurotrophic factor that protects neurons from many regions of the CNS against a wide range of neurodegenerative insults including glutamate toxicity and oxidative stress. PEDF also functions as a natural inhibitor of angiogenesis, targeting the growth of only new vessels. The 50 kD protein is encoded by a single gene that shows strong… CONTINUE READING

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