The neuroprotective agent riluzole activates the two P domain K(+) channels TREK-1 and TRAAK.

@article{Duprat2000TheNA,
  title={The neuroprotective agent riluzole activates the two P domain K(+) channels TREK-1 and TRAAK.},
  author={F Duprat and F Lesage and A J Patel and M Fink and Georges Romey and M Lazdunski},
  journal={Molecular pharmacology},
  year={2000},
  volume={57 5},
  pages={906-12}
}
  • F Duprat, F Lesage, +3 authors M Lazdunski
  • Published 2000 in Molecular pharmacology
Riluzole (RP 54274) is a potent neuroprotective agent with anticonvulsant, sedative, and anti-ischemic properties. It is currently used in the treatment of amyotrophic lateral sclerosis. This article reports that riluzole is an activator of TREK-1 and TRAAK, two important members of a new structural family of mammalian background K(+) channels with four transmembrane domains and two pore regions. Whereas riluzole activation of TRAAK is sustained, activation of TREK-1 is transient and is… CONTINUE READING
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Potassium channels with two pore domains , in Handbook of Experimental Pharmacology

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  • 1999
2 Excerpts

Potassium channels with two pore domains, in Handbook of Experimental Pharmacology. Pharmacology of ionic channel function: activators and inhibitors

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4 Excerpts

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