The neuroprotective agent riluzole activates the two P domain K(+) channels TREK-1 and TRAAK.


Riluzole (RP 54274) is a potent neuroprotective agent with anticonvulsant, sedative, and anti-ischemic properties. It is currently used in the treatment of amyotrophic lateral sclerosis. This article reports that riluzole is an activator of TREK-1 and TRAAK, two important members of a new structural family of mammalian background K(+) channels with four… (More)


5 Figures and Tables