The neuroplasticity-associated arc gene is a direct transcriptional target of early growth response (Egr) transcription factors.

@article{Li2005TheNA,
  title={The neuroplasticity-associated arc gene is a direct transcriptional target of early growth response (Egr) transcription factors.},
  author={Lin Li and John Franklin Carter and Xiaoguang Gao and Jennifer L. Whitehead and Warren G. Tourtellotte},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 23},
  pages={
          10286-300
        }
}
Early growth response (Egr) transcription factors (Egr1 to Egr4) are synaptic activity-inducible immediate early genes (IEGs) that regulate some aspects of synaptic plasticity-related to learning and memory, yet the target genes regulated by them are unknown. In particular, Egr1 is essential for persistence of late-phase long-term potentiation (L-LTP), for hippocampus-dependent long-term memory formation, and for reconsolidation of previously established memories. Here, we show that Egr1 and… CONTINUE READING

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