The neuropilins: multifunctional semaphorin and VEGF receptors that modulate axon guidance and angiogenesis.

@article{Neufeld2002TheNM,
  title={The neuropilins: multifunctional semaphorin and VEGF receptors that modulate axon guidance and angiogenesis.},
  author={Gera Neufeld and Tzafra Cohen and Niva Shraga and Tali Lange and Ofra Kessler and Yael Herzog},
  journal={Trends in cardiovascular medicine},
  year={2002},
  volume={12 1},
  pages={13-9}
}
The neuropilin-1 (np1) and neuropilin-2 (np2) receptors function as receptors for the axon guidance factors belonging to the class-3 semaphorin subfamily. In addition, both neuropilins are able to bind to certain heparin-binding splice forms of vascular endothelial growth factor (VEGF), indicating that both neuropilins have roles in the cardiovascular system as well. Gene targeting experiments indicate that np1 does indeed function as an important modulator of VEGF function during… CONTINUE READING

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