The neuropharmacology of various diazepam antagonists.

@article{Boast1983TheNO,
  title={The neuropharmacology of various diazepam antagonists.},
  author={C A Boast and Philip S. Bernard and B S Barbaz and K M Bergen},
  journal={Neuropharmacology},
  year={1983},
  volume={22 12B},
  pages={1511-21}
}
Recently, compounds which bind avidly to benzodiazepine binding sites have been shown to possess diazepam antagonist properties. For example, the benzodiazepine RO 15-1788 and the pyrazoloquinoline CGS 8216 can antagonize the anxiolytic, sedative, muscle relaxant and anticonvulsant properties of diazepam. The beta-carbolines have also been shown to antagonize several actions of diazepam. Other compounds including physostigmine, naloxone, bicuculline, picrotoxin, caffeine and theophylline, lack… CONTINUE READING
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