The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease.

@article{Rogawski2003TheNB,
  title={The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease.},
  author={M. Rogawski and G. Wenk},
  journal={CNS drug reviews},
  year={2003},
  volume={9 3},
  pages={
          275-308
        }
}
Memantine has been demonstrated to be safe and effective in the symptomatic treatment of Alzheimer's disease (AD). While the neurobiological basis for the therapeutic activity of memantine is not fully understood, the drug is not a cholinesterase inhibitor and, therefore, acts differently from current AD therapies. Memantine can interact with a variety of ligand-gated ion channels. However, NMDA receptors appear to be a key target of memantine at therapeutic concentrations. Memantine is an… Expand
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