The neuropeptide bradykinin stimulates phosphoinositide turnover in HSDM1C1 cells: B2-antagonist-sensitive responses and receptor binding studies

@article{Sharif1993TheNB,
  title={The neuropeptide bradykinin stimulates phosphoinositide turnover in HSDM1C1 cells: B2-antagonist-sensitive responses and receptor binding studies},
  author={Najam A Sharif and Roger L. Whiting},
  journal={Neurochemical Research},
  year={1993},
  volume={18},
  pages={1313-1320}
}
Bradykinin (BK) and its analogs (1 nM-100 μM) stimulated phosphoinositide (PI) turnover in murine fibrosarcoma (HSDM1C1) cells in a concentration-dependent manner. The relative potencies (EC50) were: BK=48±4 nM; Lys-BK=39±3 nM; Met-Lys-BK=158±33 nM; Des-Arg9-BK=2617±598 nM (means±SEM, n=3–14). All these analogs were full agonists and they produced up to 5.4±0.4-fold stimulation of PI turnover at the highest concentration (10–100 μM) of the peptides. In contrast, the analogs [D-Arg0-HYP3… CONTINUE READING
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