The neuropeptide alpha-MSH in host defense.

  title={The neuropeptide alpha-MSH in host defense.},
  author={A. Fede Catania and Marcello Cutuli and Letizia Garofalo and Andrea Carlin and Lorena Airaghi and Wilma Barcellini and James M. Lipton},
  journal={Annals of the New York Academy of Sciences},
The presence of the ancient peptide alpha-melanocyte-stimulating hormone (alpha-MSH) in barrier organs such as gut and skin suggests that this potent anti-inflammatory molecule may be a component of the innate host defense. In tests of antimicrobial activities, alpha-MSH and its fragment KPV showed inhibitory influences against the gram-positive bacterium Staphylococcus aureus and the yeast Candida albicans. Anti-tumor necrosis factor and antimicrobial effects of alpha-MSH suggest that the… CONTINUE READING
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