The neuropeptide PACAP attenuates beta-amyloid (1-42)-induced toxicity in PC12 cells.

@article{Onoue2002TheNP,
  title={The neuropeptide PACAP attenuates beta-amyloid (1-42)-induced toxicity in PC12 cells.},
  author={Satomi Onoue and Kosuke Endo and Keiichi Ohshima and Takehiko Yajima and Kazuhisa Kashimoto},
  journal={Peptides},
  year={2002},
  volume={23 8},
  pages={1471-8}
}
Pituitary adenylate cyclase activating polypeptide (PACAP) modulates neurotransmission in the central and peripheral nervous systems. In vitro and in vivo studies have shown the protective effects of PACAP against neuronal damage induced by ischemia and agonists of NMDA-type glutamate receptors. Here, we demonstrated that PACAP also protected against neuronal toxicity induced by beta-amyloid (Abeta) peptide, aggregation of which is a causative factor for Alzheimer's disease. PACAP (10(-9)M… CONTINUE READING

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