The neuropathology of GABA neurons in extrapyramidal disorders.

@article{Lloyd1980TheNO,
  title={The neuropathology of GABA neurons in extrapyramidal disorders.},
  author={K. Lloyd},
  journal={Journal of neural transmission. Supplementum},
  year={1980},
  volume={16},
  pages={
          217-27
        }
}
  • K. Lloyd
  • Published 1980
  • Biology, Medicine
  • Journal of neural transmission. Supplementum
  • Dysfunction of neurons in the extrapyramidal system (EPS) which use GABA as their neurotransmitter can be noted in both degenerative diseases of the EPS and in iatrogenic (i.e. drug-induced)disorders of EPS function. In Huntington's chorea there is a loss of both GABA neurons and GABA receptors in the striatum; those remaining GABA receptors likely have an altered kinetic profile, with a higher affinity for GABA than the receptors found in the non-Huntington's brain. In Parkinson's disease the… CONTINUE READING
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