The neuropathology, pathophysiology and genetics of multiple system atrophy

@article{Ahmed2012TheNP,
  title={The neuropathology, pathophysiology and genetics of multiple system atrophy},
  author={Zeshan Ahmed and Yasmine T. Asi and Anna Sailer and Andrew John Lees and Henry Houlden and Tam{\'a}s R{\'e}v{\'e}sz and Janice L. Holton},
  journal={Neuropathology and Applied Neurobiology},
  year={2012},
  volume={38}
}
  • Z. Ahmed, Y. Asi, +4 authors J. Holton
  • Published 1 February 2012
  • Biology, Medicine
  • Neuropathology and Applied Neurobiology
Z. Ahmed, Y. T. Asi, A. Sailer, A. J. Lees, H. Houlden, T. Revesz and J. L. Holton (2012) Neuropathology and Applied Neurobiology38, 4–24 
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References

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TDP‐43 pathology occurs infrequently in multiple system atrophy
TLDR
TDP‐43 pathology occurs infrequently in multiple system atrophy and this work highlights the need to understand more fully the role of TDP in disease progression.
Animal models of multiple system atrophy
TLDR
The advantages and limitations of the MSA animal models, as well as their application in preclinical target validation, are discussed and the applications of toxin and genetic approaches are reviewed.
Genetic players in multiple system atrophy: unfolding the nature of the beast
TLDR
The emerging evidence in favor of genetic players in MSA is discussed, including genes involved in oxidative stress, mitochondrial dysfunction, inflammatory processes, as well as parkinsonism- and ataxia-related genes have been implicated as susceptibility factors.
Cognitive deficits in multiple system atrophy correlate with frontal atrophy and disease duration
TLDR
This study aimed to determine the cognitive changes and brain atrophy patterns in the Parkinsonian and cerebellar variants of MSA.
Papp–Lantos inclusions and the pathogenesis of multiple system atrophy: an update
TLDR
Current biomolecular data and animal models support a crucial role of the Papp–Lantos inclusions and of aberrant αSyn accumulation as their main constituent, causing oligodendroglial pathology, myelin disruption and, finally, neuronal degeneration in MSA.
Microglia and neuroinflammation: a pathological perspective
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The role of microglia in central nervous system diseases, including infections, is discussed in terms of a participation in both acute and chronic neuroinflammatory responses.
Recent developments in multiple system atrophy
TLDR
An outline of the rationale for managing symptomatic deterioration in MSA is provided together with a summary of novel experimental therapeutic approaches to decrease disease progression.
"Minimal change" multiple system atrophy.
TLDR
It is proposed that GCIs are highly suggestive of a pathological diagnosis of MSA in the absence of detectable cell loss outside pigmented brain stem nuclei and that brains from cases of atypical parkinsonism should routinely be examined for their presence.
Multiple system atrophy: A primary oligodendrogliopathy
TLDR
The evolving concept that MSA may not just be related to Parkinson's disease but also share traits with the family of demyelinating disorders is reviewed.
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Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders.Volume editor: Dennis Dickson. Chapter editors: Catherine Bergeron, Jean-Jacques Hauw, Kurt A. Jellinger, Peter L.
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