The neuropathological phenotype in transgenic mice expressing different prion protein constructs.

@article{DeArmond1994TheNP,
  title={The neuropathological phenotype in transgenic mice expressing different prion protein constructs.},
  author={Stephen J. DeArmond and Sh. L. Yang and J Cayetano-Canlas and Darlene Groth and Stanley B Prusiner},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={1994},
  volume={343 1306},
  pages={415-23}
}
Neuropathologic examination of transgenic (Tg) mice which express different prion protein (PrP) constructs is essential because spongiform (vacuolar) degeneration of neurons, the distribution of PrPSc and whether PrP amyloid plaques form are the phenotypes of prion diseases. In Tg models of experimental scrapie, it was found that all of the parameters that define prion isolates ('strains') can be manipulated by changing the structure of PrP. In those studies, further evidence that PrPSc causes… CONTINUE READING