The neuropathological basis of clinical progression in multiple sclerosis

@article{Reynolds2011TheNB,
  title={The neuropathological basis of clinical progression in multiple sclerosis},
  author={Richard Reynolds and Federico Roncaroli and Richard Nicholas and Bishan Dass Radotra and Djordje Gveri{\'c} and Owain Howell},
  journal={Acta Neuropathologica},
  year={2011},
  volume={122},
  pages={155-170}
}
  • Richard Reynolds, Federico Roncaroli, +3 authors Owain Howell
  • Published in Acta Neuropathologica 2011
  • Biology, Medicine
  • Multiple sclerosis is the major inflammatory condition affecting the central nervous system (CNS) and is characterised by disseminated focal immune-mediated demyelination. Demyelination is accompanied by variable axonal damage and loss and reactive gliosis. It is this pathology that is thought to be responsible for the clinical relapses that often respond well to immunomodulatory therapy. However, the later secondary progressive stage of MS remains largely refractory to treatment and it is… CONTINUE READING

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