The neuropathological and behavioral consequences of intraspinal microglial/macrophage activation.

@article{Popovich2002TheNA,
  title={The neuropathological and behavioral consequences of intraspinal microglial/macrophage activation.},
  author={Phillip G. Popovich and Zhen Guan and Violeta M McGaughy and Lorryn Fisher and William Fassett Hickey and Daniel M. Basso},
  journal={Journal of neuropathology and experimental neurology},
  year={2002},
  volume={61 7},
  pages={
          623-33
        }
}
Activated microglia and macrophages (CNS macrophages) have been implicated in the secondary or "bystander" pathology (e.g. axon injury, demyelination) that accompanies traumatic or autoimmune injury to the brain and spinal cord. These cells also can provide neurotrophic support and promote axonal regeneration. Studying the divergent functional potential of CNS macrophages in trauma models is especially difficult due to the various degradative mechanisms that are initiated prior to or… CONTINUE READING

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