The neuropathic potential of anti-GM1 autoantibodies is regulated by the local glycolipid environment in mice.

@article{Greenshields2009TheNP,
  title={The neuropathic potential of anti-GM1 autoantibodies is regulated by the local glycolipid environment in mice.},
  author={Kay N. Greenshields and Susan K. Halstead and Femke M. P. Zitman and Simon Rinaldi and Kathryn M. Brennan and Colin O'Leary and Luke H Chamberlain and Alistair S. Easton and Jennifer Roxburgh and John D. Pediani and Koichi Furukawa and Carl S Goodyear and Jaap J. Plomp and Hugh John Willison},
  journal={The Journal of clinical investigation},
  year={2009},
  volume={119 3},
  pages={595-610}
}
Anti-GM1 ganglioside autoantibodies are used as diagnostic markers for motor axonal peripheral neuropathies and are believed to be the primary mediators of such diseases. However, their ability to bind and exert pathogenic effects at neuronal membranes is highly inconsistent. Using human and mouse monoclonal anti-GM1 antibodies to probe the GM1-rich motor nerve terminal membrane in mice, we here show that the antigenic oligosaccharide of GM1 in the live plasma membrane is cryptic, hidden on… CONTINUE READING
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