The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors

@article{Wu2001TheNR,
  title={The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors},
  author={Jane Y Wu and Lili Feng and Hwan-Tae Park and Necat Havlioglu and Leng Wen and Hao Tang and Kevin B. Bacon and Zhi-hong Jiang and Xiao-Chun Zhang and Yi Rao},
  journal={Nature},
  year={2001},
  volume={410},
  pages={948-952}
}
Migration is a basic feature of many cell types in a wide range of species1. Since the 1800s, cell migration has been proposed to occur in the nervous and immune systems2,3, and distinct molecular cues for mammalian neurons and leukocytes have been identified. Here we report that Slit, a secreted protein previously known for its role of repulsion in axon guidance and neuronal migration, can also inhibit leukocyte chemotaxis induced by chemotactic factors. Slit inhibition of the chemokine… CONTINUE READING
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