The neuronal nicotinic alpha4beta2 receptor has a high maximal probability of being open.

@article{Li2010TheNN,
  title={The neuronal nicotinic alpha4beta2 receptor has a high maximal probability of being open.},
  author={Ping Li and Joe Henry Steinbach},
  journal={British journal of pharmacology},
  year={2010},
  volume={160 8},
  pages={1906-15}
}
BACKGROUND AND PURPOSE A fundamental property of transmitter-gated ion channels is the probability a channel will be open (P(open)) when stimulated by a concentration of agonist that elicits a maximal response. This value is critical for interpreting steady-state concentration-response relationships in terms of channel activation, and for understanding the actions of drugs that potentiate responses. We used analysis of non-stationary noise to estimate the maximal probability the nicotinic… CONTINUE READING

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