The neuronal mechanism underlying parkinsonism and dyskinesia: differential roles of the putamen and caudate nucleus

@article{Yoshida1991TheNM,
  title={The neuronal mechanism underlying parkinsonism and dyskinesia: differential roles of the putamen and caudate nucleus},
  author={Mitsuo Yoshida},
  journal={Neuroscience Research},
  year={1991},
  volume={12},
  pages={31-40}
}
The basal ganglia were manipulated pharmacologically by using GABA antagonists and also 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in rats, cats and monkeys, and neuronal activities were recorded from the basal ganglia. It was concluded that: (1) in parkinsonism, neuronal activities of the caudate nucleus decreased, those of the pars reticulata of the substantia nigra and the internal segment of the globus pallidus increased, and those of the ventromedial nucleus of the thalamus were… CONTINUE READING